Standardized Soy Isoflavone Extract

INCI Name: Glycine Soja (Soybean) Seed Extract
Part Used: Beans from non genetically modified soy plants.
Chemistry: 10.0% minimum isoflavones consisting of
diadzein compounds
genistein compounds
glycitein compounds
Plant Description: Annual growing to 6 ft. Has leaves with 3 leaflets, white or purple flowers, and pods with 2-4 beans. Soy is native to southwestern Asia, and is cultivated worldwide in warm temperate regions.
Appearance: Light yellow to tan powder.
Soy Properties: Studies have indicated the following properties:
Antioxidant (1,2,5,6,10,11)
Anti-inflammatory (3)
Inhibits UVB Induced Skin Erythema (1,3,5,6)
Helps Prevent Photoaging (2,3,4,6,7)
UVB Protection (4,7,11)
Stimulates Collagen Synthesis (8,9)
Suppresses Sebaceous Gland Activity (8)
Inhibits Hair Growth (8)
Applications: Sun Care
Skin Care – Creams and Lotions
Skin Care – Pre and Post Tanning Treatments
Body Washes
Hair Care
Usage: 0.5%-1.0%
References:
  1. Wei, H; Bowen R; Zhang X; Lebwohi M; “Isoflavone Genistein Inhibits the Initiation and promotion of two-stage carcinogenesis in mice”, Carcinogenesis, Vol 19 1509-1514, 1998
  2. Huang ZR; Hung CF; et al, “In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzen”, International Journal of Pharmaceutics, 364 (2008) 36-44
  3. Tsu-Man Chiu, Cheih-Chen Huang; “In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake” Journal of Ethnopharmacology, 126 (2009) 108-113
  4. Moore JO; Wang Y; Stebbins WG et al; “Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis”, Carcinogenesis, vol 27 1627-1635, 2006
  5. Wei H; “Photoprotective Action of Isoflavone Genistein: Models, Mechanisms and Relevance to Clinical Dermatology”, Journal of th American Academy of Dermatology, Vol 39, 1998
  6. Kane, Janice Roma, ” Assessing Phytoestrogens as Cosmetic Active Ingredients”, Cosmetics/Personal Care CMR Focus 1999
  7. Wei H; Cai Q; O.Rahn, “Inhibition of UV Light – and Fenton Reaction – Induced Oxidative DNA damage by the soybean isoflavone genistein”, Carcinogenesis, Vol 17, 73-77, 1996
  8. Kawai N; “Phytoestrogens: Applications of Soy Isoflavones in Skin Care”, Cosmetics & Toiletries Magazine, Vol 118, 2003
  9. Sudel KM; Venzke K; Meilke H, “Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of Soy extract”, Photochemistry and Photobiology, 81, 581-587, 2005
  10. Georgetti SR; Casagrande R; Verri WA; et al, “Evaluation of in vivo efficacy of topical formulations containing soybean extract”, International Journal of Pharmaceutics, 352 (2008) 189-196
  11. Huachen Wei, Rao Saladi, et al; “Isoflavone Genistein: Photoprotection and Clinical Implications in Dermatology”, American Society for Nutritional Sciences”, 2003